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KMID : 0390119950350020125
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Journal of Pusan Medical College
1995 Volume.35 No. 2 p.125 ~ p.134
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Detection of Hepatitis B Virus DNA in Lichen Planus by the Polymerase Chain Reaction
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Abstract
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The cause and pathogenesis of lichen planus remain unknown. Considerable evidence now exists that the underlying processes involved in the pathogenesis of lichen planus are immunologically mediated. A virus has long been thought to be the
triggering
agent and many studies have demonstrated a higher incidence of liver abnormalities and HBs antigenemia in patients with lichen planus.
To clarify the relationship of Hepatitis B virus(HBV) to the development of lichen planus and the possiblity of the existence of HBV in skin, examined paraffin-embedded skin speimens from 32 cases of lichen planus by the polymerase chain
reaction.
HBV DNA was detected in 27 specimens(84.4%) out of 32 lichen planus.
Even though the liver is the main target organ in infections with HBV, this result shows that skin may also be involved with a resulting dermatoses and HBV is in some way responsible for the development of lichen planus.
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